Tag Archives: Christian John Lillis

Cipro & Levaquin can cause tendinitis & tendon ruptures

Updated 8/25/2018.

Source: MedPage Today
On top of all the other side effects caused by heavy duty, broad spectrum antibiotics like Cipro & Levaquin, I recently learned they can also cause tendinitis and ruptured tendons.
Source: Regenexx

 

 

FDA ORDERS BLACK BOX WARNINGS ON CIPRO & OTHER FLUOROQUINOLONES: THESE DRUGS MAY RUPTURE TENDONS

“Federal regulators are ordering new warnings on Cipro and similar antibiotics because of increased risk of tendinitis and tendon rupture. The new warnings apply to fluoroquinolones, a class of antibiotics that includes the popular drug Cipro….

“The warning applies to drugs of the fluoroquinolone class, including Cipro, Cipro XR, Proquin XR, Levaquin, Floxin, Noroxin, Avelox, Factive, and marketed generics….

“Most of the tendinitis and tendon ruptures affect the Achilles tendon, behind the ankle. But the agency has also received reports of tendinitis and ruptures in the shoulder and hand. Tendons connect muscle to bone.

“Officials also say they are adding new warnings cautioning that patients over 60, those taking corticosteroids, and those who’ve undergone heart, lung, or kidney transplants are also at increased risk of tendon rupture or tendinitis if they take fluoroquinolones.

“Researchers don’t know exactly what fluoroquinolones do that promotes tendon rupturing. Theories suggest the drug may impede collagen formation or interrupt blood supply in joints …

“… Patients taking the drugs should tell their doctors immediately if they experience soreness or inflammation in muscles or tendons and that they should not exercise affected joints….”

 – (Zwillich, WebMD, 2008)

 

Source: ( Dr. William E. Morgan, 2013)

 

 

 

COMMON SIDE EFFECTS OF CIPRO

 

Source: Consumer Reports
  • Abdominal pain
  • Abnormal liver function tests
  • Agitation
  • Anxiety
  • Bleeding easily
  • Blurred vision
  • Bruising easily
  • Burning in the eyes
  • Confusion
  • Dark colored urine
  • Diarrhea, watery or bloody diarrhea
  • Dizziness
  • Drowsiness
  • Fainting
  • Fast or pounding heartbeat
  • Fever
  • Hallucinations
  • Headache
  • Insomnia
  • Nausea/vomiting
  • Nervousness
  • Nightmares
  • Numbness
  • Pain behind the eyes
  • Pale or yellow skin
  • Rash
  • Ringing in the ears
  • Seizures or convulsions
  • Skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling
  • Sleep problems (insomnia or nightmares)
  • Sore throat
  • Stiffness
  • Stomach upset
  • Sudden pain
  • Swelling of the face or tongue
  • Tenderness
  • Tingling
  • Unusual pain anywhere in the body
  • Unusual thoughts or behaviors
  • Urinating less than usual or not at all
  • Vaginal itching or discharge
  • Weakness
“This is not a complete list of side effects and others may occur. “
 – Cunha, RxList, 5/14/2018

 

 

MORE SERIOUS SIDE EFFECTS OF CIPRO

Source: Drug Lawsuit Source
These are listed as  “serious and otherwise important adverse drug reactions” of Cipro, some “disabling and potentially irreversible”:
  • Tendinitis and Tendon Rupture
  • Peripheral Neuropathy
  • Central Nervous System Effects
  • Exacerbation of Myasthenia Gravis
  • Other Serious and Sometimes Fatal Adverse Reactions
  • Hypersensitivity Reactions
  • Hepatotoxicity
  • Serious Adverse Reactions with Concomitant Theophylline
  • Clostridium difficile-Associated Diarrhea
  • Prolongation of the QT Interval
  • Musculoskeletal Disorders in Pediatric Patients
  • Photosensitivity/Phototoxicity
  • Development of Drug Resistant Bacteria
– (Cunha, RxList, 5/14/2018)

 

 

CONDITIONS TREATED WITH CIPRO

Source: SFGate
You can see from the following WebMD list of conditions treated with Cipro that this broad spectrum antibiotic is commonly used to combat a wide variety of established bacterial infections and is sometimes even given prophylactically :
  • intestine infection due to the Shigella bacteria
  • Intestinal Infection due to Campylobacter
  • Traveler’s Diarrhea
  • Acute Maxillary Sinus M. Catarrhalis Bacteria Infection
  • Pneumonia caused by Proteus Bacteria
  • Urinary Tract Infection caused by Klebsiella Bacteria
  • Infection of the Prostate Gland caused by Proteus
  • Continuous Bacterial Inflammation of the Prostate Gland
  • Skin Infection
  • Bone Infection caused by Enterobacter
  • Lower Respiratory Tract Infection
  • Complicated Peritonitis caused by E. Coli
  • Abscess Within the Abdomen
  • Infection of Urinary Tract due to Pseudomonas Aeruginosa
  • Urinary Tract Infection caused by Serratia
  • Skin Infection due to Klebsiella Bacteria
  • Acute Maxillary Sinus H. Influenzae Bacteria Infection
  • Complicated Peritonitis caused by Proteus Bacteria
  • Bacterial Infection of Kidney due to E. Coli Organism
  • Bladder Infection caused by E. Coli
  • Urinary Tract Infection due to E. Coli Bacteria
  • Infection of the Urinary Tract caused by Proteus Bacteria
  • Skin Infection due to Staphylococcus Aureus Bacteria
  • Skin Infection due to Streptococcus Pyogenes Bacteria
  • Skin Infection due to Enterobacter Bacteria
  • Pneumonia caused by Bacteria
  • Infection Within the Abdomen
  • Urinary Tract Infection due to Staphylococcus Epidermidis
  • Skin Infection due to E. Coli Bacteria
  • Skin Infection due to Citrobacter Bacteria
  • Infection of Bone
  • Prevention of Plague Following Exposure to Plague
  • Bacterial Pneumonia caused by Klebsiella
  • Staphylococcus Saprophyticus Infection of Urinary Tract
  • Infection of the Prostate Gland caused by E. Coli
  • Skin Infection due to Proteus Bacteria
  • Skin Infection due to Pseudomonas Aeruginosa Bacteria
  • Skin Infection due to Providencia Bacteria
  • Infection of a Joint caused by Serratia Bacteria
  • Treatment to Prevent Anthrax following Exposure to Disease
  • Pneumonia due to the Bacteria Haemophilus Parainfluenzae
  • Pneumonia caused by E. Coli Bacteria
  • Infection of Urinary Tract due to Providencia Species
  • Urinary Tract Infection caused by Citrobacter
  • Skin Infection caused by Morganella Morganii
  • Joint Infection caused by Pseudomonas Aeruginosa Bacteria
  • Bone Infection caused by Serratia Bacteria
  • Pneumonia caused by the Bacteria Enterobacter
  • Complicated Peritonitis caused by Pseudomonas Aeruginosa
  • Complicated Peritonitis caused by Klebsiella Bacteria
  • Bladder Infection caused by Staphylococcus
  • Infection of the Urinary Tract caused by Enterococcus
  • Joint Infection caused by Enterobacter Species Bacteria
  • Infection of a Joint
  • Diarrhea caused by E. Coli Bacteria
  • Bacterial Urinary Tract Infection
  • Typhoid Fever
  • Diarrhea caused by a Bacteria
  • Plague
  • Acute Maxillary Sinus S. Pneumoniae Bacteria Infection
  • Pneumonia caused by the Bacteria Pseudomonas Aeruginosa
  • Bacterial Pneumonia caused by Haemophilus Influenzae
  • Pneumonia caused by Gram-Negative Bacteria
  • Bronchitis caused by the Bacteria Moraxella Catarrhalis
  • Complicated Peritonitis caused by Bacteroides Bacteria
  • Infection of Urinary Tract due to Enterobacter Cloacae
  • Urinary Tract Infection caused by Morganella Morganii
  • Skin Infection due to Staphylococcus Epidermidis Bacteria
  • Bone Infection caused by Pseudomonas Aeruginosa
  • Short-Term Infection with Diarrhea
  • Discomfort & Weight Loss
  • Diverticulitis
  • Diabetic Foot Infection
  • chancroid
  • Heart Valve Infection caused by Haemophilus
  • Pneumonia caused by the Bacteria Anthrax
  • Cystic Fibrosis and Infection from Pseudomonas Bacteria
  • Bacterial Stomach or Intestine Infection caused by Anthrax
  • Infection of the Brain or Spinal Cord caused by Anthrax
  • Urinary Tract Infection Prevention
  • Skin Infection caused by Anthrax
  • Treatment to Prevent Traveler’s Diarrhea
  • Treatment to Prevent Meningococcal Meningitis
  • Presumed Infection in Neutropenic Patient With Fever
 – (WebMD, 2018)

 

 

LEVAQUIN

Source: best-price-checker.com
The uses, potential side effects and warnings for Levaquin are similar to those for Cipro. See Levaquin (RxList, 2018A) if you want to check it out specifically.

 

Source: HealthHearty

 

 

FDA SAYS TO USE FLUOROQUINOLONES ONLY AS A DRUG OF LAST RESORT

 

Source: Drugwatch.com
The American Academy of Family Physicians (AAFP) posted this warning on July 27 2016:
“According to a July 26 FDA Drug Safety Communication these medications have been associated with disabling and potentially permanent side effects involving tendons, muscles and/or joints, as well as peripheral nerves and the central nervous system. Some patients may even experience more than one such adverse effect.
“Therefore, said FDA officials, fluoroquinolones should be used in patients with acute bacterial sinusitis (ABS), acute bacterial exacerbation of chronic bronchitis (ABECB) or uncomplicated urinary tract infections (UTIs) only when no other treatment options are available, “because the risk of these serious side effects generally outweighs the benefits in these patients.”
“‘Fluoroquinolones have risks and benefits that should be considered very carefully,’ said Edward Cox, M.D., director of the Office of Antimicrobial Products in the agency’s Center for Drug Evaluation and Research, in (a news release). ‘It’s important that both health care providers and patients are aware of both the risks and benefits of fluoroquinolones and make an informed decision about their use.’
“The agency has revised the boxed warning for all drugs in this class of antibiotics to reflect these serious safety concerns. Those drugs are
  • moxifloxacin (Avelox)
  • ciprofloxacin (Cipro)
  • ciprofloxacin extended-release (Cipro extended-release)
  • gemifloxacin (Factive)
  • levofloxacin (Levaquin) and
  • ofloxacin (Ofloxacin generic brand)….
Specific events reported include
  • tendinitis and tendon rupture,
  • muscle pain or weakness,
  • joint pain and/or joint swelling,
  • peripheral neuropathy, and
  • central nervous system effects (e.g., psychosis, anxiety, depression, suicidal thoughts).
“Effects can begin within hours of starting the medications, but they may not be seen until after weeks of treatment. Patients should be advised to discontinue the drugs immediately if they experience any serious adverse effects.
“The benefits of fluoroquinolones continue to outweigh the risks when used for certain serious bacterial infections (e.g., pneumonia, intra-abdominal infections) and the FDA says it is appropriate for them to remain available as a therapeutic option in such cases.”
 – (AAFP, 2016) & (FDA, 2016)
Source: medium.com

 

FOLLOW AN ANTI-INFLAMMATORY REGIMEN IF YOU NEED TO TAKE ONE OF THESE ANTIBIOTICS

Since antibiotics target the good (probiotic)  bacteria in and on the body right along with their intended target, harmful bacteria, also be sure to take lots of the probiotic yeast, Sacharomyces boulardii, to protect your gut microbiome from being overrun by pathogenic bacteria anytime you’re given a course of antibiotics. This includes antibiotics you receive unbeknownst to you in your IV along with the anesthetic during surgeries. And remember that you can talk with your surgeon about exactly which antibiotic you’ll be given during surgery and why.
Sacharomyces boulardii is a probiotic YEAST, not a bacterium, so is not targeted by antiBIOTICS and can act as a place holder in your gut microbiome to fill up the space created when an antibiotic kills off your good bacteria.
See this earlier post for more information on Sacharomyces boulardii.
Dr Gabrielle Francis, who alerted me to the tendinitis and tendon rupture warnings for Cipro and Levaquin, recommends following this anti-inflammatory regimen during and for at least three months after a course of one of these antibiotics has been finished:
GLUCOSAMINE SULFATE (integrative Therapeutics) – to lubricate and strengthen tendons, build and support joint cartilage: 1 at breakfast/1 at dinner
BIOINFLAMAX (Nutra BioGenesis) – to maintain a healthy inflammatory response in joint and muscles: 2 at breakfast/2 at dinner
MAGNESIUM MALATE (Designs for Health or Integrative Therapeutics) – to protect joints and muscles: 1 at breakfast/1 at dinner
OSTEOFORCE SUPREME (Designs for Health) – to support bone health: 1 at breakfast/1 at dinner
For more information on these supplements (benefits, ingredients list, side effects, interactions), see:
Glucosamine Sulfate
BioInflamax
What Are the Benefits of Magnesium Malate? and Magnesium Malate
OsteoForce Supreme
Source: The Herban Alchemist
In addition, Dr Francis recommends having a detoxifying smoothie for breakfast to keep your body strong while taking antibiotics. This is her version, the Detox Smoothie Bundle. Drink the detox smoothie in the AM and take the antibiotic in the PM.
Visit Dr Francis’s website, The Herban Alchemist, if you want to read more about her.

ARE THESE DANGEROUS ANTIBIOTICS GIVEN TO FACTORY FARMED ANIMALS?

Source: Healthy Market
Yes.
“The federal government must crackdown on the use of antibiotics such as cephalosporins and fluoroquinolones within the nation’s meat industry because of the threat that antibiotic resistance poses to public health, says one of the government’s leading veterinary drug safety officials.” (Webster, 2008)

 

Regions that produce the most pork and chicken also use the most antibiotics on farms. Hot spots around the world include the Midwest in the U.S., southern Brazil, and China’s Sichuan province. Yellow indicates low levels of drug use in livestock; orange and light red are moderate levels; and dark red is high levels.

Source: PNAS
If you eat meat made from factory farmed animals, you’re also consuming a variety of antibiotics – possibly including fluoroquinones – in each juicy burger, serving of fried chicken, and side of bacon you enjoy.

 

Source: winstonclose
Factory farmed animals (cows, pigs, chickens) are given fluoroquinones – among other antibiotics. (Doucleff, 2015) & (FDA, 2009). The 2009 FDA report lists 2 fluoroquinones and 47 other approved antibiotics for use on factory farmed cows. You can see the report for yourself: Antimicrobials Sold or Distributed for Use in Food-Producing Animals .

 

 

Source: The Outdoor Journal
I was also trying to track down which antibiotics are known to be given to farm raised fish in the US and elsewhere and found only these five that have been detected in aquacultured fish:  oxytetracycline, 4-epioxytetracycline, sulfadimethoxine, ormetoprim, and virginiamycin.
But, lest you think wild caught seafood is antibiotic-free, oxytetracycline has also been detected  in wild-caught shrimp from Mexico, perhaps from coastal pollution, sewage contamination, mislabeling, or cross-contamination during handling and processing. (Lueing, 2015)

 

Source: MicrobeWiki
And, in case you noted the dates of the articles and the report cited above and figure the FDA has surely fixed the problem by now, here’s a quote from a recently published article on the rise of antibiotic resistant illnesses:
“The overuse and misuse of antibiotics in the meat industry is contributing to the rise of antibiotic-resistance in the U.S. and across the world. This serious public health issue is estimated to kill 10 million people a year worldwide by 2050. In the U.S., antibiotic-resistant infections cause over two million illnesses and 23,000 deaths each year, costing society between $55 billion to $70 billion each year.
“The majority of antibiotics in the U.S. are given to animals that are not sick; they are mixed into animals’ food and water to make them grow bigger or to prevent illness in cramped and unhealthy environments.” (As You Sow, 6/14/2018)

 

Source: The Hearty Soul

 

Many thanks to Dr Gabrielle Francis for alerting me to this situation and recommending the protocol of supplements to take during and after a course of Cipro or Levaquin as protection against tendon damage.

 

 

 

HOW LEVAQUIN TURNED RACHEL BRUMMERT INTO A PATIENT ADVOCATE

Almost immediately after I published this post, Christian John Lillis, Executive Director of The Peggy Lillis Foundation (Lillis, 2018), sent me this article his friend Rachel Brummert just posted on DrugWatch.com about the  dozens of spontaneous tendon fractures she has experienced after taking Levaquin for a suspected sinus infection:  Levaquin Turned Me into ‘Frankenwoman’. (Brummert, 8/24/2018)
Source: Alliance for the Prudent Use of Antibiotics
These ghastly experiences motivated her to become a  trained Patient Advocate through the National Center for Health Research and a trained Special Government Employee (SGE) through the U.S. Food and Drug Administration. She also works with the Centers for Disease Control and Prevention (CDC) on fluoroquinolone awareness communication campaigns.
Christian John Lillis and his brother Liam started The Peggy Lillis Foundation to fight Clostridium difficile by building a nationwide Clostridium difficile awareness movement that educates the public, empowers advocates, and shapes policy. Peggy Lillis, Christian and Liam’s mother,  died at age 56  after having a root canal and being prescribed the antibiotic Clindamycin to treat a dental abscess. Seven days later she became septic and went into cardiac arrest from the massive C. diff infection that had taken over her colon. (Peggy Lillis Foundation, 2018)
Source: Alliance for the Prudent Use of Antibiotics
“(Clindamycin) increases the risk of hospital-acquired Clostridium difficile colitis about fourfold.” (Wikipedia, 7/26/2018)
Source: beforeyoutakethatpill.com

 

 

REFERENCES

American Academy of Family Physicians (AAFP.) (July 27, 2016). Use Fluoroquinolones Only as Drug of Last Resort for Some Infections. See: https://www.aafp.org/news/health-of-the-public/20160727fluoroquinolones.html

As You Sow. (6/14/2018). Antibiotics & Factory Farms. See: https://www.asyousow.org/our-work/environmental-health/antibiotics-factory-farms/

Brummert, R. (8/24/2018).  Levaquin Turned Me into ‘Frankenwoman’. DrugWatch.com. See: https://www.drugwatch.com/beyond-side-effects/levaquin-turned-me-into-frankenwoman/?utm_source=facebook&utm_medium=post-organic

Cunha, J.P.  (5/14/2018). Cipro: Side Effects Center. RxList. See: https://www.rxlist.com/cipro-side-effects-drug-center.htm#overview

Doucleff, M. (2015). For The Love Of Pork: Antibiotic Use On Farms Skyrockets Worldwide. NPR. See: https://www.npr.org/sections/goatsandsoda/2015/03/20/394064680/for-the-love-of-pork-antibiotic-use-on-farms-skyrockets-worldwide

FDA. (2009). SUMMARY REPORT on Antimicrobials Sold or Distributed for Use in Food-Producing Animals. Center for Veterinary Medicine. See: https://grist.files.wordpress.com/2010/12/ucm231851.pdf

FDA. (7/26/2016). FDA Drug Safety Communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. See: https://www.fda.gov/Drugs/DrugSafety/ucm511530.htm

Francis, G. (2018). Personal communication.

Francis, G. (2018). Detox Smoothie Bundle. See: https://store.theherbanalchemist.com/collections/smoothie-bundles-1/products/zzzdet

Francis, G. (2018). The Herban Alchemist. See: http://theherbanalchemist.com

Hardin, J.R. (2014). Sacharomyces boulardii. See: https://allergiesandyourgut.com/superimmunity/saccharomyces-boulardii/

Hutchins, M. (2017). What Are the Benefits of Magnesium Malate?. LiveStrong. See: https://www.livestrong.com/article/280804-what-are-the-benefits-of-magnesium-malate/

Lillis, C.J. (2018). Personal communication.
Luening, E. (2015). Study identifies antibiotics in farm raised seafood. Aquaculture North America. See: https://www.aquaculturenorthamerica.com/research/survey-identifies-antibiotics-in-farm-raised-seafood-1559

 

Morgan, W.E. (2013). Tendon Rupture Related to Antibiotic Use: Fluoroquinolone induced tendon ruptures are a growing concern. See: http://drmorgan.info/clinicians-corner/tendon-rupture-related-to-antibiotic-use/

Peggy Lillis Foundation. (2016). See: https://peggyfoundation.org/about-plf/about-peggy/

Pure Formulas. (2018A). BioInflamax. See: https://www.pureformulas.com/bioinflammatory-plus-120-capsules-by-biogenesis-nutraceuticals.html

Pure Formulas. (2018 B). Magnesium Malate. See: https://www.pureformulas.com/magnesium-malate-chelate-240-tablets-by-designs-for-health.html

Pure Formulas. (2018 C). OsteoForce Supreme. See: https://www.pureformulas.com/osteoforce-supreme-180-capsules-by-designs-for-health.html

RxList. (2018 A). Levaquin. See: https://www.rxlist.com/levaquin-drug.htm

RxList (2018 B).  Glucosamine Sulfate. See: https://www.rxlist.com/glucosamine_sulfate/supplements.htm#HowDoesItWork

WebMD. (2018). What Conditions does Cipro Treat? See: https://www.webmd.com/drugs/2/drug-1124-93/cipro-oral/ciprofloxacin-oral/details/list-conditions

Webster, P.C. (2008). Crackdown on factory farm drug use urged. Canadian Medical Association Journal, 184:1, E23–E24.

Wikipedia, 7/26/2018). Clindamycin. See: https://en.wikipedia.org/wiki/Clindamycin

Zwillich, T. (7/28/2008). FDA Warning: Cipro May Rupture Tendons: Agency Issues ‘Black Box’ Warning for Antibiotics Known as Fluroquinolones. WebMD. See: https://www.webmd.com/osteoarthritis/news/20080708/fda-warning-cipro-may-rupture-tendons

 

© Copyright 2018. Joan Rothchild Hardin. All Rights Reserved.

DISCLAIMER:  Nothing on this site or blog is intended to provide medical advice, diagnosis or treatment.

ANTIBIOTICS, THE GUT MICROBIOME & THE REST OF THE BODY

 

(Source: fatburningman.com)

 

Christian John Lillis, of the Peggy Lillis Foundation, sent this text to me yesterday:

At a talk by Bruce Hirsch on FMT and he just said, referring to antibiotics, “What happens in the gut doesn’t stay in the gut.” I thought that was well put.

–   Christian John Lillis on 3/9/2016

Well put indeed! Dr Hirsch succinctly summed up, in one short sentence, antibiotics’ huge, deleterious impact on the probiotic bacteria living in our gut microbes … and from there to the rest of  the body. Wreck your gut microbiome and you’re wrecking your health.

 

Bruce E. Hirsch, MD

Specialist in Infectious Disease & Geriatric Medicine

dr-bruce-e-hirsch-md-11308126

 

If you wish to read more about Dr Hirsch and fecal-derived microbiota transfers (FMT) for recurring Clostridium difficile infections, see: After Antibiotics, the Feces Pill Remains (Khazan, 2013) and Effectiveness of fecal-derived microbiota transfer using orally administered capsules for recurrent Clostridium difficile infection (Hirsch et al, 2015).

 

 

About the Peggy Lillis Foundation:
images

 

The mission of the Peggy Lillis Foundation is to build a nationwide clostridium difficile awareness movement by educating the public, empowering advocates, and shaping policy.
The PLF envisions a world where C. diff is rare, treatable and survivable.

 

What is Clostridium difficile infection?

“Clostridium difficile [pronounced Klo-STRID-ee-um dif-uh-SEEL], also known as “C. diff” [See-dif], is a germ that can cause diarrhea. Most cases of C. diff infection occur in patients taking antibiotics. The most common symptoms of a C. diff infection include:

  • Watery diarrhea
  • Fever
  • Loss of appetite
  • Nausea
  • Belly pain and tenderness “
– Centers for Disease Control and Prevention, 2015

 

 

 

probiotics-vs-antibiotics

 

 

REFERENCES

Centers for Disease Control and Prevention. (2015).  Clostridium difficile Infection Information for Patients. See: http://www.cdc.gov/hai/organisms/cdiff/Cdiff-patient.html

Hirsch et al. (2015). Effectiveness of fecal-derived microbiota transfer using orally administered capsules for recurrent Clostridium difficile infection. BMC Infectious Diseases, 15:191. See: http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-0930-z

Khazan, O. (2013). After Antibiotics, the Feces Pill Remains. The Atlantic. See: http://www.theatlantic.com/health/archive/2013/12/after-antibiotics-the-feces-pill-remains/281925/

Lillis, C.J. (3/9/2016). Personal communication.

Peggy Lillis Foundation. (2016). See: http://peggyfoundation.org

 

 

© Copyright 2016. Joan Rothchild Hardin. All Rights Reserved.

DISCLAIMER:  Nothing on this site or blog is intended to provide medical advice, diagnosis or treatment.

 

BIMUNO – PREbiotics for Anxiety, OCD, Depression & Overall Health

 

 

prebiotics-and-probiotics-14-638

 

I was looking for a non-pharmaceutical way to help my anxious and OCD patients so asked my supplements guru, David Miller, MD at LifeThyme (a health food store in NYC). He sent information about a new PREbiotic supplement that’s been demonstrated to be helpful for anxiety and OCD thinking – and the entire immune system located in the gut microbiome. It’s called Bimuno®. (Miller, 2015)
Bimuno® isn’t readily available yet in the US but can be ordered from the company’s website in England. Research on it and the information on the company’s site are very interesting.
It comes as sachets of tasteless powder to sprinkle over food or add to drinks and also as soft chewable pastilles. I just ordered some (the pastilles) to try myself – especially to use during travels outside the country, which often lead to upsets in my gut microbiome.
images-4
Bimuno® is a new PREbiotic product that feeds the good, PRObiotic bacteria living in our guts (such as Lactobacilli and Bifidobacteria) to the detriment of the bad bacteria (pathogens). As the good bacteria multiply, they flush out the bad bacteria.
WHAT COULD BE BETTER!?

 

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DIFFERENCE BETWEEN PRE- AND PRO-BIOTICS

 

case-study-kiwifruit-extract-subpage-probiotics-prebiotics
PREBIOTICS are specialized plant fibers containing complex sugars (such as inulin,  fructo-ogliosaccharides and galacto-oligosaccharides) that are indigestible by humans but promote the growth of beneficial bacteria (PROBIOTICS) living in our gut microbiomes by serving as food for them.
PROBIOTICS are helpful, live bacteria and yeasts our bodies need to function and maintain good health. They are found in fermented foods such as kefir, live-culture yogurt, real sauerkraut and pickles (not ones made with vinegar), kimchi, kombucha and other naturally fermented foods. If our gut flora has already become seriously out of balance, we can also benefit from taking high quality probiotics as supplements to populate the necessary array of friendly bacteria in our gut microbiomes. There are hundreds of probiotic species living in the human gut – some that are known to be ancient life forms and many that scientists haven’t even been able to identify yet.
Sometimes PREBIOTICS and PROBIOTICS are combined in the same supplements, called SYNBIOTICS.
See my earlier posts Prebiotics and Probiotics and  PREbiotics and PREbiotics for more information.

 

 

prebiotics-and-probiotics-41-638

 

 

 

 

 

SCIENTIFIC BASIS FOR THIS PREBIOTIC PRODUCT’S EFFICACY

From the Bimuno® website:

Scientific studies have demonstrated that Bimuno can significantly increase levels of Bifidobacteria (good bacteria) in the gut.1

Bimuno is the only second generation Galacto-oligosaccharide prebiotic available. It is a truly unique prebiotic with a powerful Bifidogenic effect.

3D Model of the patented prebiotic galacto-oligosaccharide

Bimuno’s unique galacto-oligosaccharide structure

It selectively boosts Bifidobacteria which play a key role in immune function and maintaining and building a healthy digestive system.

Bimuno is the result of many years of intensive research by a team of international digestive health experts and the University of Reading.

A number of clinical trials have been published and there is an ongoing research and development program into Bimuno across a number of health areas including:

  • The Immune system
  • Various aspects of digestive Health
  • Digestive health while abroad
  • Various aspects of human metabolism

Reference: 1. Am J Clin Nutr 2008; 87 :785-91

 

Bimuno® original powder is the natural way to increase and energise your good gut bacteria helping you to manage your gut health.  Bimuno works in a similar way to prebiotics naturally found in human breast milk which promote a healthy bacterial balance within the gut.

Scientific studies indicate that the unique second generation Galacto-oligosaccharide formulation of Bimuno powder, can help to encourage and sustain a healthy level of your friendly gut bacteria(Bifidobacteria). In fact Bimuno has the most potent bifidogenic (Bifidobacteria promoting) effect of any available prebiotic.

Published scientific studies have shown that, with daily use, the majority of Bimuno users experience a significant increase in their gut Bifidobacterium within just 7 days.

This in itself is impressive but by a unique anti-adhesive action it also helps flush ‘bad’ bacteria from your gut at the same time for a healthy microflora balance.

Give your digestive system a healthy boost

Bimuno powder:

  • Increases your Bifidobacteria levels, helping to maintain a healthy intestinal balance.
  • Reduces gas producing bacteria
  • Reduces bad bacteria levels
  • Energises your friendly gut bacteria
  • By maintaining a healthy digestive balance you can support overall well-being

 

 

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GUT DYSBIOSIS AND ANXIETY

Christian John Lillis, of the Peggy Lillis Foundation, reports noticing an uptick in the number of people on Clostridium difficile Facebook groups who mention that they’re also struggling with anxiety. (Lillis, 2015)
This overlap between C. diff (a serious bacterial infection of the colon) and anxiety isn’t at all surprising. An out of balance (dysbiotic) gut microbiome produces a wide variety of symptoms – including anxiety, depression, and OCD.

 

http://www.peggyfoundation.org/
http://www.peggyfoundation.org/

 

 

Animal studies have previously shown a link between mood and brain function and probiotics in the gut microbiota. Ingestion of Lactobacillus rhamnosus (a strain of PRObiotic) has been demonstrated to modulate information processing strongly linked to anxiety and depression and to improve the neuro-endocrine stress response in lab animals – in plain English, this probiotic turned anxious, fearful mice into mellow ones.
Now new research on healthy human adults conducted by a group of neurobiologists at Oxford University demonstrated that supplementation with PREbiotics (Bimuno® galacto-oligosaccharides, B-GOS) lowered the subjects’ neuro-endocrine stress responses and increased their ability to  process positive versus negative attentional vigilance. In other words, PREbiotic supplementation with Bimuno REDUCED THEIR ANXIETY LEVELS AND OCD THINKING.
The researchers assessed how subjects processed emotional information, such as positively and negatively charged words, after they’d been taking the prebiotic supplement. Results showed that the supplemented group paid less attention to negative information and more attention to positive information than either a group given another type of prebiotic (fructooligosaccharides, FOS) or a group given a placebo. The people who had taken Bimuno® also had lower levels of cortisol (a stress hormone linked with anxiety and depression) in their morning saliva.
A similar effect has been observed in people taking anti-depressants and anti-anxiety pharmaceutical medication. (Schmidt et al, 2014) (Gregoire, 2015)
This is very good news for people suffering from anxiety and OCD. Taking a prebiotic supplement may relieve their life-impinging symptoms while also improving their overall physical health – without the adverse effects of pharmaceuticals.

 

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BIMUNO‘S INGREDIENTS

Information listed on the box of Bimuno powder sachets:
  • Galacto-oligosaccharides (GOS)
  • Lactose (from milk)
  • Glucose syrup
  • Thickener (gum arabic)
  • Galactose
  • Acidity regulator (trisodium citrate)
  • Free from artificial colors, flavours and preservatives
  • Gluten-free
  • 16 Cal/sachet
The galacto-oligosaccharides in Bimuno® are a mixture of disaccharides, trisaccharides, a tetrasaccharide and a pentasaccharide.

 

 

 

 

THE BIMUNO WEBSITE

I recommend checking out the Bimuno website. The pull down menus are chock full of useful and fascinating information about digestive and whole body health, prebiotics/ probiotics and the immune system.
See the information under:
  • Maintain your digestive health
  • Digestive problems & solutions
  • Support your immune defences
  • Digestive health for traveling

 

 

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REFERENCES

Bimuno. (2015). Bimuno’s website. See: http://www.bimuno.com/

Depeint, F. et al. (2008). Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity ofBifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study. See: http://ajcn.nutrition.org/content/87/3/785.full

Gregoire, C. (2015). The Surprising Link Between Gut Bacteria And Anxiety. The Huffington Post. See: http://www.huffingtonpost.com/2015/01/04/gut-bacteria-mental-healt_n_6391014.html

Hardin, J.R. (2013). Probiotics and Probiotics. AllergiesAndYourGut.com. See: http://allergiesandyourgut.com/superimmunity/prebiotics-and-probiotics/

Hardin, J.R. (2014). PREbiotics and PRObiotics. AllergiesAndYourGut.com. See: http://allergiesandyourgut.com/?s=prebiotics

Lillis, J.C. (2015). Private communication.

Miller, D. (2015). Private communication.

Schmidt, K. (2014). Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. See: http://link.springer.com/article/10.1007%2Fs00213-014-3810-0

Vulevic, J. et al. (2008). Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. See: http://ajcn.nutrition.org/content/88/5/1438.short

 

 

© Copyright 2015 Joan Rothchild Hardin. All Rights Reserved.

 

DISCLAIMER:  Nothing on this site or blog is intended to provide medical advice, diagnosis or treatment.