Tag Archives: Intestinal Villi

IntestiNEW to Strengthen Your Digestive Lining

Updated 3/9/2016.

gutbacteria8

Our gut microbiomes, the several pounds of micro-organisms living inside our intestines and often referred to as Our Friends with Benefits,  affect pretty much every aspect of  our health – keeping us well or making us sick.

 

(Source: www.goodgirlgogogo.com)
(Source: www.goodgirlgogogo.com)
I wrote about INCREASED GUT PERMEABILITY – CAUSES & CONSEQUENCES in a 10 May 2015 post. Here’s part of that article as background for appreciating the value of a supplement called IntestiNEW that strengthens the intestine’s mucosal lining, where our gut microbiomes reside:

 

 

DIGESTION – FROM MOUTH TO ANUS

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The human digestive tract runs from the mouth at the top to the anus at the other end. Foreign matter (food) is taken in and partially broken down by chewing in the mouth. It then travels down through the esophagus to the stomach and from there into the small and large intestines, where it is selectively digested. During this trip, various phases of digestion take place  and nutrients are extracted and absorbed. The liver, gall bladder and pancreas, organs that aid in the digestive process, are located along the length of the GI tract.
The total length of the GI tract varies from person to person. In an adult male the range is 20 to 40 feet. On average, the small intestine in adults is 22 feet long and the large intestine is 5 feet.
As you can intuit, a lot could go wrong during that long trip – and much of that depends on the quality of what you deliver to your mouth as ‘food’.
(Source: sanjosefuncmed.com)
(Source: sanjosefuncmed.com)

 

You can see the location of the mucosal layer (called ‘mucous coat’ in the diagram below) and the intestinal villi in this cross section of the human small intestine. The empty space in the center, just below the villi (the spikes you see in the image of a healthy mucosal membrane in the image to the left above),  is called the lumen, the tube in which food travels through the intestines.

excret_intestin_coupe_FF_en

(Source: MyHumanBody.ca)

 

 

 

INCREASED GUT PERMEABILITY – AKA LEAKY GUT

(Source: scdlifestyle.com)
(Source: scdlifestyle.com)
Increased gut permeability – also known as hyper-permeable intestines or “leaky gut” – describes the intestinal lining’s having become more porous than it should be so the process of what is allowed out into the body no longer functions properly.  Larger, undigested food molecules and other bad things (such as yeasts, toxins, and other forms of waste  that normally would continue on and get excreted through the anus) flow freely through these too-large holes in the intestinal lining and enter the bloodstream, where they don’t belong and are treated as dangerous invaders.
The  gut’s mucosal layer is thin, delicate – and very important. This is where our probiotic bacteria live, so degrading it also degrades the strength of our immune systems. The probiotics residing in the gut mucosal layer make up 70-90% of the human immune system.
Damage to the gut’s mucosal layer leads to a whole range of serious problems as the body tries to cope with the invaders being released into the bloodstream. Once this lining has become disturbed, allowing problematic things to flow through it into the blood stream, a cycle of chronic irritation begins, leading to chronic inflammation in the body and a whole series of autoimmune conditions.
wpid-screenshot_2014-09-22-18-44-15-11
It is well-known that the composition of the gut lining and its microbiota changes during animal development and can be influenced by environmental factors such as diet, lifestyle, and habitat. (Barker, 2013), (Conlon, 2014) & (Renew Life, undated)
So you can see the importance of keeping your gut lining, where those critters live, in good shape.

 

 

REGENERATION OF THE GUT LINING

 

(Source: www.stemcell.com)
(Source: www.stemcell.com)
The thin lining of our intestines is semi-permeable: a healthy lining membrane  allows nutrients to pass from the intestines into the bloodstream and prevents toxins, pathogens, and undigested food from exiting the digestive tract too early. When the lining becomes chronically damaged, allowing toxins, pathogens, and undigested food to  enter the bloodstream, chronic inflammation occurs in the body and many negative, autoimmune health conditions may ensue. (Renew Life, undated)
See AUTOIMMUNE DISEASES: How they develop and how to put them in remission (Hardin, 2014) for more information.
A healthy intestinal lining serves many functions, most critical among them:
  • Continuing the digestive processing of food after it leaves  the stomach
  • Absorbing nutrients from this partially digested food
  • Preventing harmful bacteria and undigested food particles from entering the bloodstream
Like our skin, the delicate mucosal lining of our small and large intestines sloughs off a layer of cells every 3-5 days and produces new cells to maintain its semi-permeable state. This process requires the amino acid L-Glutamine. (Renew Life, undated).
“Small populations of adult stem cells are responsible for the remarkable ability of the epithelial lining of the intestine to be efficiently renewed and repaired throughout life.” (Barker, 2013)
The human body’s GI tract is lined with mucosal tissues primarily comprised of epithelial cells attached to the underlying membrane. Tiny, finger-like projections called villi protrude from the intestinal walls and greatly increase their absorptive and surface areas.
“Digested nutrients (including sugars and amino acids) pass into the villi through diffusion. Circulating blood then carries these nutrients away.  Unlike the mucosal tissue of the inner surface of the eyelids or the mouth, the epithelial cells which line the inside of the stomach are exposed to much harsher conditions, e.g., acid (i.e., hydrochloric acid), sometimes alcohol, enzymes (e.g., pepsin) for digesting food and waste generated therefrom. Mucous secretion essentially protects the cells on the inside of the stomach and duodenum from damage by acid or enzymes, for example by presenting bicarbonate to neutralize some of the effects of acid on the stomach’s inner lining, as well as inhibitors to block the enzymatic activity. Once the mucous secretions of the epithelial cells stop, the inner lining of the stomach or duodenum would eventually be eroded by the combined action of acid and enzymes, leading to ulcer.” (MEBO, 2009)

 

 

INTESTINEW

IntestiNew is a dietary supplement designed and produced by Renew Life to soothe the digestive system and benefit the health of the mucosal lining of the intestines. It is available as a powder or in capsules.
intestinew-1The capsule form contains L-glutamine, N-acetyl D-glucosamine, gamma oryzanol, cranesbill root, ginger root, marigold flower, marshmallow root, vegetable fiber, and water.

DIG-IntestiNEWCaps-0813

The powder form contains the same ingredients with the exception of the vegetable fiber and water.

DIG-IntestiNEWPowder-0813

The glucosamine, L-glutamine, and the herbs in IntestiNew soothe and support the integrity of the intestinal lining.  The gamma oryzanol, a natural extract of rice oat bran, delivers essential antioxidant benefits to the digestive system. (Holt, 2016)
Both forms of the supplement are gluten free and contain no artificial ingredients.
Women who are pregnant, nursing, or trying to conceive are advised to consult their physicians before taking IntestiNEW, as are people taking pharmaceutical medications or having a medical condition.  The supplements contain an ingredient derived from crustacean shells (shrimp, lobster, and/or crab) so aren’t suitable for people with a shellfish allergy.

 

Time-to-balance-your-gut-health.-Before-the-bad-bugs-have-a-party.jpg

Although I couldn’t find any scientific papers on IntestiNEW, it has been well reviewed by customers on Amazon, iHerb, The Vitamin Shoppe, Vitacost,  and National Nutrition. I second those reviews: Since I’ve been taking IntestiNEW, I’ve seen a big improvement in my digestive health. I started with a scoop (5.4 grams) stirred into an eight ounce glass of filtered water before breakfast and now take two capsules before each meal, with water)

 

Some of the many ways our gut bacteria affect our health:
(Source: www.huffingtonpost.com)
(Source: www.huffingtonpost.com)
My thanks to David Miller, MD, Supplements Specialist at Life Thyme Market in New York City, for recommending IntestiNew to me.

 

Colonoscopy-cartoon1

 

REFERENCES

Barker, N. (2013). Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration.  Nature Reviews Molecular Cell Biology 15:  19–33. See: http://www.nature.com/nrm/journal/v15/n1/full/nrm3721.html

Conlon, M.A. et al. (2015). The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients. 7(1): 17–44. See: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303825/

Hardin, J.R. (26 October 2014). AUTOIMMUNE DISEASES: How they develop and how to put them in remission. See: http://allergiesandyourgut.com/2014/10/26/autoimmune-diseases-develop-put-remission/

Hardin, J.R. (10 May 2015). INCREASED GUT PERMEABILITY – CAUSES & CONSEQUENCES. See: http://allergiesandyourgut.com/2015/05/10/increased-gut-permeability-causes-consequences/

Holt, L. (2016). IntestiNew Reviewed: Does IntestiNew Work? Daily Health Answers. See: https://www.dailyhealthanswers.com/intestinew-reviewed.html

MEBO. (2009). Regeneration of Gastro- Intestinal Tract. Human Body Regeneration Sciences. See: http://en.mebo.com/about/ShowInfo.asp?InfoID=1

Renew Life. (undated). INTESTINEW: Natural Ingredients Used Traditionally to Support a Healthy Intestinal Lining. See: http://www.renewlife.com/media/spec_sheets/SpecSheetRNLIntestiNew.pdf

 

 

© Copyright 2016. Joan Rothchild Hardin. All Rights Reserved.

 

DISCLAIMER:  Nothing on this site or blog is intended to provide medical advice, diagnosis or treatment.

 

Good Gut Daily – Good News for Your Gut & Overall Health

Updated 5/24/2015. Last updated 5/25/2015.

 

images

 

Those of us living in developed countries where we have multiple food choices often focus on our calorie intake while neglecting the health of our gut microbiome – the vast numbers and variety of microorganisms inside our intestines. We’re talking about several pounds of tiny critters – 10’s of trillions of them, including about 1,000 different species of bacteria made up of over 3 million genes  all living and working in our intestinal walls to digest our food and keep our bodies healthy.

 

The-microbiome

 

Some of the important functions of those multitudinous microorganisms in our guts (Gut Microbiota WorldWatch, 2015):
  • Helping digest foods that the stomach and small intestine have not been able to digest
  • Helping produce some vitamins (B and K)
  • Helping combat aggressions from other microorganisms
  • Maintaining the integrity of the intestinal mucosa
  • Playing an important role in the immune system, performing a barrier effect

 

Gut Microbiome

(Source: www.diapedia.org)
(Source: www.diapedia.org)

 

If you’re not keeping those pounds of critters healthy and in balance, you’re likely to become ill – perhaps not in the short run but as you move along through your life. The kinds of illnesses and conditions we’re talking about include acne, allergies, asthma, autism, cancer, celiac disease, Crohn’s disease, depression, diabetes, eczema, endocrine imbalances, endometriosis, Graves’ disease, some heart disease, infertility, juvenile arthritis, lupus, Lyme disease (chronic), MS, myesthenia gravis, peripheral neuropathy, psoriatic arthritis, psoriasis, rheumatic fever, rheumatoid arthritis, ulcerative colitis, vitiligo … and many more.

 

(Source: livegracefully.com)
(Source: livegracefully.com)

 

 

 

A HEALTHY VERSUS A DAMAGED GUT LINING

Isn’t the image below graceful and beautiful? It shows the villi, mucosal cells in the lining of a healthy small intestine. The mucosal layer is where our probiotic microorganisms live and work. It’s also home to the body’s largest population of immune cells.

 

(Source: library.med.utah.edu)
(Source: library.med.utah.edu)

 

Now compare that lovely image to the one below. This person’s  intestinal villi have been seriously damaged by celiac disease:
(Source: commons.wikimedia)
(Source: commons.wikimedia)
Here’s another image of damaged intestinal villi. There are holes where there should be intact cells that allow only needed nutrients to get through the intestinal walls into the blood stream. These holes allow larger particles of undigested food and toxins through and the body attacks them as invading pathogens, producing an inflammatory response.

 

(Source: www.slideshare.net)
(Source: www.slideshare.net)

 

 

 

THE CONNECTION BETWEEN AN UNHEALTHY GUT MICROBIOME, CHRONIC INFLAMMATION AND AUTOIMMUNE DISEASES

As someone who’s now having to work hard to repair a very damaged gut lining and reverse several autoimmune conditions – the result of being given infant formula instead of breast milk, childhood exposure to heavy metals (fluoride in my formula and in my city’s water supply, mercury fillings), many courses of antibiotics in adulthood – I assure you it’s wise to nurture your gut microbiome so your gut lining resembles that first, beautiful slide above and is never  allowed to turn into the second or third.
A diagram of how damage to the intestinal lining leads to increased gut permeability – also called Leaky Gut:

 

(Source: nothippyjusthealthy.com)
(Source: nothippyjusthealthy.com)

 

And another graphic depicting how damage to the gut’s mucosal lining allows undigested food particles and toxins to escape into the body, where they cause an inflammatory response. Chronic inflammation –> autoimmune responses –> disease.
(Source: www.wakingtimes.com)
(Source: www.wakingtimes.com)

 

See INCREASED GUT PERMEABILITY – CAUSES & CONSEQUENCES  for more information on Leaky Gut and some great images of what the inside walls of our intestines look like.

 

Dr-Jill-Carnahan-Leaky-Gut

 

 

 

 

POLYPHENOL PREBIOTICS HELP HEAL DAMAGED GUT LININGS

Now that we’ve covered the importance of the probiotic microorganisms living in your gut microbiome, I hope you’re ready for some really good news!
It’s about polyphenols and how they can help us repair our overall health by restoring the health of our gut linings. Polyphenols are a type of PREbiotic, the kind of nutrient that feeds your PRObiotics.

PREbiotics and PRObiotics

(Source: sitn.hms.harvard.edu)
(Source: sitn.hms.harvard.edu)
Polyphenols are anti-oxidant micro-nutrients derived from a variety of plants that increase the amount of good bacteria (probiotics) and inhibit  the amount of bad bacteria in our guts. They also act as PREbiotics. (Marksteiner, 2014)
This table shows the 100 richest sources of dietary polyphenols. (Pérez-Jiménez, 2015)
Strong evidence is accumulating that polyphenols’ play an important role in preventing degenerative diseases such as cancer and cardiovascular diseases. (Manach et al, 2004)

Now a start up company in California, Greenteaspoon, has formulated a combination of nutrients called Preliva™ from plant extracts rich in polyphenols.

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GOOD GUT DAILY – GOOD NEWS FOR DAMAGED GUT LININGS

Prepare for a radical improvement in your digestion and your general health! Greenteaspoon’s Good Gut Daily is a tasty, liquid dietary supplement containing antioxidant, PREbiotic polyphenols for protecting or rebuilding a healthy gut.
Preliva™, the proprietary active formula in Good Gut Daily, is made from plant extracts rich in bio-available polyphenols. The results of a large double-blind and placebo-controlled clinical study, published in the  peer-reviewed publication the World Journal of Gastroenterology (Noguera et al, 2014), strongly support the prebiotic potential of the polyphenol blend in Preliva™ to:
  • Strengthen the protective digestive lining
  • Nourish the body’s good microflora (the friendly digestive microbes living in our guts
  • Reduce digestive distress – diarrhea, stomach discomfort and bloating
  • Calm digestion
  • Reduce inflammation
  • Strengthen your immunity
  • Fight immune burnout
  • Combat symptoms of stress
  • Support your overall well being

lactobacillus-feed-me

Greenteaspoon makes three versions of Good Gut Daily in a variety of  flavors and sizes:

 

GOOD GUT DAILY NATURAL IMMUNE HEALTH

 

12-oz-GGDIH-Pom_front_medium_6e8373cf-cd71-493b-832e-d826e0f0e15a_large

Good Gut Daily Natural Immune Health is formulated to strengthen your immunity and support your overall well-being.
Good Gut Daily Natural Immune Health is designed for people with ongoing digestive problems, food sensitivities or ‘leaky gut’ symptoms – including acute digestive issues like gastroenteritis, travelers sickness, diarrhea, gas, bloating, or an upset stomach. Taken daily, it protects your digestive system and can decrease digestive distress.
What it does:
  • Fights immune burnout
  • Clinically proven to calm digestion
  • Reinforces your digestive lining
  • Combats symptoms of stress, diarrhea, stomach discomfort and bloating
Who it’s for:

Good Gut Daily Natural Immune Health is for people actively trying to improve and manage their ongoing immune health.

Flavors:
  • Pomegranate-Blueberry
  • Mango Passion Fruit
Available in three sizes:
  • 2-oz quick-shots (sold in 12-packs)
  • 12-oz bottles (12 servings)
  • 32-oz (32 servings)
Safe for children over age 2 and for adults of all ages.

 

 

 

GOOD GUT DAILY NATURAL DIGESTIVE HEALTH

 

12_Day_Supply_Good_Gut_Mango_large

Good Gut Daily Natural Digestive Health is designed to help you manage your ongoing digestive issues. Taken daily, it protects your digestive system and can decrease digestive distress.
What it does:
  • Calms Your Digestive System
  • Clinically Shown to Alleviate Occasional:
  •            Diarrhea
  •            Upset stomach
  •            Gas and bloating
  •  Nourishes Your Body’s Good Microflora
Who it’s for:

Good Gut Natural Digestive Health is for people with ongoing digestive problems, food sensitivities or ‘leaky gut’ symptoms – including acute digestive issues like Gastroenteritis, travelers sickness, diarrhea, gas, bloating or an upset stomach.

Flavors:
  • Cranberry-Raspberry
  • Orange-Mango
Sizes:
  • 2-oz quick-shots (sold in 12-packs)
  • 12-oz (12 servings)
  • 32-oz (32 servings)
Safe for children over age 2 and for adults of all ages.

 

GOOD GUT RESCUE

 

2-oz-GGR-Mint-12-pack_box_0e26d09c-2bf0-4d3d-a76b-5f987e811b84_large

Double strength Good Gut Rescue rapidly soothes the symptoms of digestive distress, alleviating occasional diarrhea, upset stomach, gas and bloating. Good for rapid-onset upset stomach and handy for travel.
What it does:
  • Clinically Shown to Alleviate:
    • Diarrhea
    • Upset Stomach
    • Gas & Bloating
Who it’s for:

Good Gut Rescue is for children and adults ages 2 and up with acute digestive issues like gastroenteritis, travelers sickness, diarrhea, gas and bloating or upset stomach.

How it works:
  • Strengthens the protective digestive lining
  • Supports friendly digestive microbes
  • Reduces digestive distress
  • Reduces inflammation
Flavors:
  • Soothing Mint
  • Honey Ginger
Sizes:
  • 2-oz quick-shots (sold in 12-packs)
Safe for children over age 2 and for adults of all ages.

 

 

 

Ingredients NOT in Good Gut Daily

All the versions of Good Gut Daily contain NO calories, sugar, gluten, soy, dairy, or GMOs – and come with a 30-day money back guarantee.

 

(Source:www.savorylotus.com)
(Source:www.savorylotus.com)

 

 

 

 

TO BUY GOOD GUT DAILY

Good Gut Daily isn’t available at stores yet. You can order it on the Greenteaspoon website to try it for yourself.
Remember: If your gut microbiome is balanced and healthy, the rest of your body will be a nice happy place to live too.

 

(Source: http://charansurdhar.com/is-your-microbiome-happy/)
(Source: http://charansurdhar.com/is-your-microbiome-happy/)

 

 

A Personal Note:

My experience with Good Gut Daily is that it greatly improved my GI health (which had become bad again a few months ago) in just a few days (4 to be exact) – alone, without taking any of my usual PRObiotics or other nutritional supplements.
I started with a single 1-oz dose of Good Gut Daily’s Natural Digestive Health (the Mango-Passion Fruit flavor) and then increased to 1 oz in the AM (on an empty stomach, 30 minutes before breakfast)  + another 1 oz 30 minutes before dinner. This 1 oz twice a day dosing calmed down my over-active gut and gave me back my energy, which had been disturbingly low during the previous weeks of GI upset.
I’ve been taking Good Gut Daily for about seven weeks now. My gut and the rest of my body never want to be without it. Rob Wotring, Greenteaspoon’s Founder and Chief Scientific Officer, is currently engaged in clinically testing a pill version for travel. I’m hoping it’ll be available before I leave for a long vacation this fall.

 

(Source: www.probiotein.com)
(Source: www.probiotein.com)

 

Rob Wotring at Greenteaspoon told me: “We’re convinced polyphenol prebiotics will play a huge role in advancing our understanding of the importance of the gut mucus layer in health and wellness.” Many highly respected scientists, doctors, and other health care professionals agree.

 

 

polyphenols_top_sources

 

REFERENCES

Good Gut Daily. (2015). Website. See: http://goodgutdaily.com/

Gut Microbiota WorldWatch. (2015). Everything you always wanted to know about the gut microbiota… See: http://www.gutmicrobiotawatch.org/en/gut-microbiota-info/

Hardin, J.R. (2015). Increased Gut Permeability – Causes & Consequences. AllergiesAndYourGut.com. See: http://allergiesandyourgut.com/2015/05/10/increased-gut-permeability-causes-consequences/

Manach, C. et al. (2004). Polyphenols: food sources and bioavailability. American Journal of Clinical Nutrition, 79:5, 727-747. See: http://ajcn.nutrition.org/content/79/5/727.full

Marksteiner, K. (2014). Do Polyphenols Improve Your Gut Bacteria? See: http://chriskresser.com/do-polyphenols-improve-your-gut-bacteria/

Noguera, T. et al. (2014). Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic. World Journal of  Gastroenterology, 29:34, 12301-12307. See: http://www.wjgnet.com/1007-9327/full/v20/i34/12301.htm

Pérez-Jiménez, J. et al. (2015). Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. European Journal of Clinical Nutrition. See http://www.nature.com/ejcn/journal/v64/n3s/fig_tab/ejcn2010221t1.html

 

© Copyright 2015 Joan Rothchild Hardin. All Rights Reserved.

 

DISCLAIMER:  Nothing on this site or blog is intended to provide medical advice, diagnosis or treatment.